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The area under the concentration curve obtained when administered at the same dose, corresponds approximately to twice that obtained when it is applied by oral or rectal route, as the active principle is metabolized almost 50% during its first passage through the liver (first pass effect), when administered by the routes mentioned

Seizure management: Treat seizures

In 2009, EMA approved liraglutide for treatment of type 2 diabetes (T2D), followed by the approval of semaglutide for T2D treatment in 2018

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Blood 131 , 558562 (2018)