It is still an investigational drug
Documenting and Analyzing Observations Thorough documentation of all observations and data is non-negotiable
Users stopping retinoids frequently report rapid regression of benefits within 4-8 weeks including increased breakouts sometimes exceeding pre-treatment levels (retinoid rebound), accelerated fine line reappearance approaching or surpassing baseline, skin texture deterioration returning to pre-treatment roughness, and psychological dependency from dramatic visible decline creating pressure for continuous use despite side effect burden
When compared to Phentermine, Semaglutide demonstrated significant associations with lower oculomotor binocular dysfunction (HR 0.42, 95% CI: 0.270.66, p = 1 10 4 ), dry eye disease (HR 0.61, 95% CI: 0.380.99, p = 0.044), ametropic accommodative dysfunction (HR 0.44, 95% CI: 0.280.70, p = 3.1 10 4 ), and visual disturbances (HR 0.71, 95% CI: 0.510.98, p = 0.038), while cataracts (HR 0.56, 95% CI: 0.311.00, p = 0.047) and visual issues and blindness (HR 0.77, 95% CI: 0.571.06, p = 0.105) showed borderline or non-significant associations
J Biol Chem (1989) 264:128269
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