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Secondary outcomes Five included studies comprising 3605 patients reported change in MCV, four studies comprising 140 patients reported change in homocysteine levels, four studies comprising 3588 patients reported change in platelets count, and only three studies with 3430 patients reported change in WBC count

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However, development was discontinued in 2007 after the largest Phase IIb trial failed to demonstrate statistically significant weight loss compared to placebo

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Typically once weekly, though some protocols use twice-weekly dosing

Good to know: For people who cant absorb vitamin B12 from their diet or oral tablets, prescription vitamin B12 treatment is usually a lifelong medication