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However, chronic stress can disrupt this feedback loop

10.1016/j.vph.2018.02.010 100 VukojeviJ.VrdoljakB.MalekinuiD.SiroglaviM.MilaviM.KolencD.et al (2020)

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These guidelines, while a starting point, are often based on a one-size-fits-all model (e.g., 8 or 12-weekly injections) that does not work for all patients

It means either the dose is wrong, the compound doesnt work for you, the product quality is poor, or the effect size is below what you can detect subjectively

By your 40s, the effects are clearly visible: fine lines, sagging skin, reduced elasticity, and a dull complexion