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9 Research gaps and future priorities 9.1 Reproductive-oriented RCTs: shifting from metabolic surrogates to hard endpoints To date, most GLP-1RA trials in PCOS have been designed around metabolic efficacy (weight change and insulin-resistance/glycaemic indices) as the primary outcomes, with reproductive outcomesovulation, clinical pregnancy, and live birthreported inconsistently and often as secondary or exploratory measures

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Standard-dose protocols may also make sense for patients who are motivated by measurable progress and want a more direct treatment path

Whats happening now is like a large-scale, open-label, public human trial thats being done on these drugs, the long-term consequences of which we dont know, noted Phillips