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and those with a BMI over 35.

It is approved in Russia as a nootropic and neuroprotective drug (ischemic stroke, cognitive impairment)

Although the mechanisms of action of SCS have not been clearly identified, it is thought to involve both spinal and supraspinal effects and has been shown to be effective for the treatment of various neuropathic pain such as failed back surgery syndrome and complex regional pain syndrome [97-100]

At the same time, the equity questions are just as important as the efficacy curves: Who will actually have access to orforglipron once it is approved

K.TokeB.et al (2012)

The most common side effects are nausea, vomiting, diarrhoea, constipation, stomach pain, and acid reflux, and these are usually reduced by starting on a low dose and increasing it gradually