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Thyroid tumors : Some studies suggest that GLP-1 drugs may increase the risk of developing thyroid tumors, including cancer

chronic stress dampens satiety signals

Zepbound (tirzepatide) produces approximately 5% to 8% more weight loss than Wegovy (semaglutide 2.4 mg) based on cross-trial comparisons

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Fewer patients had impaired glucose tolerance and saw their cholesterol profiles improve Trial #6 was the nail in the coffin: The group taking AOD-9604 and the group taking the placebo were also following a strict diet and exercise routine over the entire 24-week period yet the weight loss induced in the AOD-9604 group was not statistically significant (at least not compared to HGH)

And shortly after that came something even worse