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Naked or poorly protected mRNA is inherently unstable and can be rapidly degraded by extracellular and intracellular ribonucleases

Neural Regeneration Research, 17(3), 482-487

GLP-1s are in essence chemicals that the body produces in response to food

Common: appetite changes, fatigue, yawning Many users report eating less, feeling sleepy, or yawning soon after a dose

Many online sources cite milligram-level dosing (0.1 mg to 0.5 mg), which is 100 to 500 micrograms total and sits at the higher end of or above what formal research used on a per-kilogram basis for a typical adult