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Kozakova M, Palombo C, Paterni M, Dekker J, Flyvbjerg A, Mitrakou A, Gastaldelli A, Ferrannini E

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Vasoconstriction is caused by noradrenaline activated alpha-1 adrenergic receptor released from sympathetic ganglion neurons

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Therapeutic levels are achieved within 624 hours after one injection, with monthly doses of 50, 75, or 100 mg