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Peroxynitrite is highly toxic to neurons and causes hyper-excitability of the central nervous system, a process known as "kindling." This leads to autonomic nervous system dysfunction (dysautonomia), sensory overload, and severe cognitive deficits
When the gene has either of these two variants, the resulting MTHFR enzyme is slightly less active, which can lead to lower levels of folate, and higher levels of homocysteine
Kress CL, Konopleva M, Martnez-Garca V, Krajewska M, Lefebvre S, Hyer ML, McQueen T, Andreeff M , Reed JC, Zapata JM
Best for: Event-prep, dilute injectables, custom cocktails with prescription ingredients
2020;doi:10.1038/s41572-020-0160-6