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The 4-PBA group showed mild sinusoidal congestion with focal hepatocyte necrosis as manifested by nuclear pyknosis, karyorrhexis, and karyolysis with cytoplasmic eosinophilia (Figure 8A), yet it significantly attenuated histopathological scoring compared to MTX-group (Figures 8BD)

Primers (Integrated DNA technologies, Singapore) used for PCR reactions were listed in Table 1

c-MET inhibitors have shown promising pre-clinical and early phase clinical trial anti-tumor activity in several tumor types, although results of most phase III trials with these agents have been negative

doi:10.1006/bbrc.1999.1010

The Wnt/beta-catenin pathway also governs cutaneous wound healing, and CXXC5 negatively regulates this process as well

Anderson, 2006