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Ample clinical trial data has established unequivocally that lowering low-density lipoprotein (LDL) ("bad cholesterol") with statins and other drugs in appropriately selected patients delivers meaningful cardiovascular risk reduction

However, BDNF mimetic peptides like LM22A-4, GSB-106, and PE-22-28 are designed to activate the same TrkB receptors with better bioavailability

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166.7 mg

doi: 10.1371/journal.pone.0308092 85 Martinez-FierroMLGarza-VelozIRojas-MartinezAOrtiz-LopezRCastruita-de La RosaCOrtiz-CastroYet al

In addition, dysregulation of CPT1 has been implicated in the development of such metabolic disorders as obesity, metabolic-associated fatty liver disease (MAFLD), diabetic cardiomyopathy and the metabolic syndrome