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Bronchial hyperresponsiveness (BHR) is a hallmark of chronic asthma, is linked with disease severity, and is a consequence of changes in ASM tone [11, 59]

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Underwriters therefore need to continue to review and assess medical evidence for any associated side effects and potential comorbidities, including cardiovascular status, renal and hepatic function, and mental health or cognitive concerns

as illustrated in Figure 3C, the protein levels of ABCA1 were significantly increased by PARP-1 knockdown or PARP-1 inhibitor 3-AB, compared with those in the control or si-NC (negative control) group

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