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Pellets are compounded bioidentical hormones

Because the intranasal forms have lower absorption than the IM dosage form, intranasal B12 forms are administered once weekly

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In UK practice, monitoring is primarily based on clinical response rather than routine blood tests

Regulatory guidance from the Food & Drug Administration (FDA) and WHO emphasizes that proper aseptic technique, storage procedures, environmental controls, and documentation practices remain essential regardless of the presence of preservatives