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The Kidney Disease Improving Global Outcomes 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease recommends adults with CKD and either an eGFR 20 mL/min/1.73 m 2 or higher plus UACR of 200 mg/g or higher, or those with heart failure, receive SGLT2 inhibitor therapy

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Supports the insulin resistance and metabolic-health discussion around glutathione, oxidative stress, and glucose metabolism.

[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Oem JK, Jackel-Cram C, Li YP, Zhou Y, Zhong J, Shimano H, Babiuk LA, Liu Q

Key Benefits : Average weight loss of 13 15% at 68 weeks in clinical trials