Overexpression of GSTP1 resulted in a two-fold increase in GSH-conjugation of the QIs, attenuated QI-induced cytotoxicity especially under GSH-depletion condition, abolished QIs-induced apoptosis but did not significantly inhibit the activation of the ER stress response
Ferroptosis results from increased lipid peroxidation caused by GPX4 deficiency
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Therefore, Alzheimers disease (AD), characterized by cognitive impairment and memory loss, is inevitably influenced by the accumulation of TMAO
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