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The barrier to entry is multi-layered

that patients take their medication as prescribed) is fundamental to achieving the best outcomes for people taking obesity medications [25,121,122]

Fishery Technology 33 , 8490 (1996)

Importantly, dissatisfaction and discontinuation were more strongly associated with minimal weight loss and nongastrointestinal side effects than with common gastrointestinal complaints, suggesting that for many users, perceived effectiveness outweighed tolerability concerns

doi: 10.1056/NEJMoa1411892, 72