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GSH-triggered prodrugs Because intracellular GSH levels are typically elevated in tumor cells relative to normal tissues, this redox imbalance has been exploited as a tumor-associated trigger for prodrug activation and selective cytotoxicity 214

Accordingly, PASC could be described as a SARS-CoV-2-induced chronic and self-perpetuating comprised state of m- Dys, where OxS potentially drives inflammation and shifts energy metabolism towards glycolysis while down-regulating OXPHOS 27,142,143

Insights from animal models and postmortem tissue examined the impact of acute infection on BBB integrity

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Therefore, it is not possible to estimate the contribution of each thyroid disease to a worse prognosis of COVID-19