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Treatment with FOS and GOS also reduced TNF-, COX-2, Caspase-3, Iba-1, and GFAP-positive cells in the dentate gyrus, decreasing neuroinflammation and neuronal death caused by chronic HFD consumption

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Phentermine is in the class of drugs called anorectics, also known as appetite suppressants, and has been used consistently for medical weight management since it was first approved in 1959