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Aberrant activation of specific transcriptional programs has the capacity to greatly alter cellular state, driving oncogenesis and supporting cancer cell proliferation

Immune system regulation

Cole TA, Zhao H, Collier TJ, Sandoval I, Sortwell CE, Steece-Collier K, Daley BF, Booms A, Lipton J, Welch M, Berman M, Jandreski L, Graham D, Weihofen A, Celano S, Schulz E, Cole-Strauss A, Luna E, Quach D, Mohan A, Bennett CF, Swayze EE, Kordasiewicz HB, Luk KC, Paumier KL (2021) -Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinsons disease