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We need to acknowledge the complexity of the disease [of obesity] and the complexity of well-managed care, and that the relationship between the two is key. Tracy Zvenyach GLP-1s Are Safe Although GLP-1s have only recently become well-known to the public, they have been used to treat diabetes for 20 years, and there are many studies that show that these drugs are both safe and effective

In a randomized, placebo-controlled study, pemvidutide, a dual GLP-1/GCG receptor agonist, significantly decreased liver fat content by up to 68.5% after 12 weeks of treatment, accompanied by reductions in hepatic inflammation markers and body weight, highlighting the potential of dual receptor agonists to modify MASLD pathophysiology (47)

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Research shows that fermentable fibers specifically stimulate GLP-1 production as gut bacteria break down these fibers into short-chain fatty acids

Neural Regeneration Research , 17(3), 482