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Summary: Retatrutide is an investigational triple receptor agonist (GLP-1, GIP, and glucagon) showing promising early weight-loss and metabolic data in Phase 2 trials, but it is not yet approved in the UK and carries notable side effects and safety uncertainties

[12] Reports on its development state that it was engineered for activity across these targets

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First, osteoarthritis is one of the most common chronic pain conditions globally and is directly worsened by excess body weight

Industry analysts project a potential launch in 2028, though timelines could shift depending on regulatory review

A maintenance dose is typically 25 to 50% of the therapeutic dose