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150,152,153 Activation of the GLP-1R can enhance insulin secretion, reduce glucagon secretion, delay gastric emptying, 154 and suppress appetite

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The practical cost comparison: | Medication | Monthly Cash Price | Typical Insurance Copay | Duration | |---|---|---|---| | Generic lisdexamfetamine | $30 to $80 | $10 to $35 | 12 to 13 hours | | Generic mixed amphetamine salts XR | $15 to $50 | $5 to $25 | 10 to 12 hours | | Generic methylphenidate ER (osmotic) | $20 to $45 | $5 to $25 | 10 to 12 hours | | Brand Vyvanse | $350 to $450 | $40 to $75+ | 12 to 13 hours | | Brand Concerta | $300 to $400 | $35 to $60 | 10 to 12 hours | | Brand Adderall XR | $280 to $380 | $35 to $60 | 10 to 12 hours | Non-Stimulant Alternatives and Their Costs Some patients cannot tolerate stimulants or have contraindications such as uncontrolled hypertension, cardiac arrhythmias, or active substance use disorders

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The FDA guidelines (for women, which clinicians also follow for men) say no more than one dose in 24 hours, and no more than 8 doses per month