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On the same presynaptic terminus of dopaminergic neurons, there are dopamine D2 receptors (D2R) serving as a presynaptic auto-inhibitory receptor, which is implicated in the regulation of DAT functions

miR-146a, microRNA-146a

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In clinical studies, while the direct effects on -synuclein aggregation in humans are still being investigated, improvements in motor function, cognitive abilities, and general neuronal health have been observed, suggesting that GLP-1 RAs are impacting these pathological processes