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Its largest positions include Eli Lilly (NYSE:LLY) at 10.50%, Johnson & Johnson (NYSE:JNJ) at 7.19%, and AbbVie (NYSE:ABBV) at 4.88%

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Numerous factors affect outcomes including starting weight, baseline metabolic health status, genetic and hereditary factors, adherence to prescribed treatment protocols, concurrent lifestyle modifications including dietary changes and physical activity increases, duration of treatment, individual medication response variability, underlying health conditions, stress levels and cortisol patterns, sleep quality and duration, hormonal factors, age, sex, medications affecting metabolism, gut microbiome composition, previous weight loss history and metabolic adaptation, and countless other variables

Animal and cell studies show shifts in enzymes that convert cholesterol to sex steroids, suggesting possible effects on estrogen and testosterone levels