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And some never achieve consistent enough absorption for meaningful results

2025 Dec;193

In certain embodiments, any controlled-release otic formulation described herein increases the exposure of an active agent and increases the Area Under the Curve (AUC) in otic fluids (e.g., endolymph and/or perilymph) by about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, about 100%, or higher than 100%, compared to an otic formulation that is not a controlled-release otic formulation

Moon MJ, Park S, Kim DK, Cho EB, Hwang JI, Vaudry H, Seong JY

This unique complex significantly increases biotin solubility 40 times greater than that of D-biotin, the type commonly found in beauty products

doi:10.1002/ijc.28393 155