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Changes in bowel habits that are severe or persistentsuch as bloody stools, black tarry stools, or diarrhoea lasting more than a few daysrequire medical evaluation to rule out other causes

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Further information was retrieved from the American Diabetes Association (ADA), Clinicaltrials.gov and clinicaltrials.eu websites

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This occurs when your bone marrow produces unusually large, immature red blood cells that cant carry oxygen properly