semaglutide cvot Cardiovascular Outcomes Trial (CVOT) Researchers compare tirzepatide and semaglutide

This observation raises the possibility of direct anti-inflammatory or central effects

While GLP-1 and GIP receptor agonists are highly effective for initiating caloric deficits, human metabolism is highly adaptive

For example, interleukin-1, which triggers cell activation by binding to specific membrane receptors, plays a key role in initiating an inflammatory cascade, but interleukin-10, produced by microglia and astrocytes and lymphopoietic cells, appears to play a neuroprotective role by producing anti-inflammatory cytokines

2020 Sep 13:961203320957721

doi: 10.1007/s11064-012-0775-4 132 EndresDTebartz van ElstLMeyerSAFeigeBNickelKBublAet al

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