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In vivo studies using a potassium oxonate/hypoxanthineinduced acute hyperuricemia model showed a significant hyperuricemia effect of compounds 55 , 56, and 58 , consistent with the in vitro inhibition results, but they did not show uric acidreducing activity as good as that of the drug febuxostat [72]
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In particular, an increase in lipoperoxide (LPO) levels damages the endothelial cells in the large intestine and exacerbates the symptoms of colitis, which can develop into colon cancer 3
2023 Feb;29(Suppl):S17-S31
Peer-reviewed preclinical literature references BPC-157 in laboratory studies involving angiogenic signaling, nitric oxide pathway interactions, fibroblast migration, collagen synthesis, and gastrointestinal biology
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