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and (3) obesity-related adipose tissue expansion triggers a chronic low-grade systemic inflammatory response, in which pro-inflammatory cytokines (such as IL-6 and TNF-) can directly act on the anterior pituitary gland, enhancing prolactin secretion
(2009) Pharmacological dose of vitamin B12 is as effective as low-dose folinic acid in correcting hyperhomocysteinemia of hemodialysis patients
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In the UK, hydroxocobalamin is the preferred injectable formulation prescribed by the NHS for treating confirmed B12 deficiency
The standard dosing schedule starts with 0.25 mg weekly for the first four weeks, increases to 0.5 mg weekly from weeks five through eight, and then may escalate to 1 mg or 2 mg weekly depending on tolerance and response
Weight gain and body composition changes Unexplained weight gain, particularly central abdominal fat, may be hormonally mediated
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