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escalation stops once the effect target is met and tolerated

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Journal of Clinical Pharmacy and Therapeutics, 47(4), 543-556

If the frequency and cost criteria thresholds for a complexity adjustment are met and reassignment to the next higher cost APC in the clinical family is appropriate (based on meeting the criteria outlined above), we make a complexity adjustment for the code combination

This established the mechanistic rationale for NNMT inhibition