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8-13 For a detailed discussion of cardiovascular outcome trials (CVOTs) completed with agents from the GLP-1 RA class, please refer to the companion lesson titled: What do we Currently Know about the Cardiovascular Benefits of GLP-1 RAs

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Melanotan II also decreases fluorodeoxyglucose uptake in atherosclerotic plaques, decreases pro-inflammatory cytokine levels, and increases aortic vasorelaxation in animal models of atherosclerosis

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However, such coverage comes with strict eligibility requirements, such as patients needing an extremely high BMI and associated health conditions