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At one end of the spectrum, metabolic dysfunction-associated steatotic liver (hepatic steatosis, MASL) may progress to a more advanced state called metabolic dysfunction-associated steatohepatitis (MASH) characterized by significant hepatocyte damage, inflammation, and pericellular fibrosis, and further to cirrhosis (Friedman et al

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This suggests that GPX3 may contribute to the maintenance of stem cell properties of OCSCs within the TME by influencing lipid metabolism in tumor cells (97)