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The mechanism is direct: less 5-MTHF less methionine regeneration less SAM less DNMT activity progressive CpG demethylation at aging-clock sites accelerated measured epigenetic age

Lee J, Hong SW, Kim MJ, Kwon H, Park SE, Rhee EJ, et al

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Frequency and dosage depend on factors like medical condition, response to treatment, age, diet, and overall health

Some users notice improvements in how they feel during recovery within the first week or two

Knowing who should avoid these drugs helps patients make safer decisions with their healthcare providers