Curcumin inhibits APAP-induced hepatocyte apoptosis by reducing the expression of pro-apoptotic genes Bax and caspase-3, inducing anti-apoptotic genes like Bcl-x1, and increasing the ratio of Bcl2/Bax (Somanawat et al., 2013)
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It also helps to boost the production of other antioxidants such as vitamin C and E
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Clinically, patients typically notice these appetite changes within the first few weeks of treatment, with effects becoming more pronounced as the dose is titrated upward according to FDA-approved protocols
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