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Individual results vary based on lifestyle modifications, metabolic factors, and adherence to weight maintenance strategies implemented after discontinuation

HPC = Hippocampus

Endogenous Histamine and Cortisol Levels in Subjects with Different Histamine N-Methyltransferase C314T Genotypes: A Pilot Study. Molecular Diagnosis & Therapy, vol

By the end of the first month, most patients report a significant reduction in nausea severity, even if mild symptoms linger occasionally with certain foods

Future prospectively designed longitudinal studies should include a longitudinal aspect from the outset to increase retention and balance the time between study visits between groups

The article treats that as the mechanism behind regain rather than a failure of willpower, since the medication temporarily addresses an underlying metabolic condition and the appetite signal returns when it is withdrawn