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In conclusion, within the gut-organ axis, TMAO is closely associated with the pathological changes of various chronic diseases by regulating processes such as apoptosis, pyroptosis, abnormal autophagy, and ferroptosis

While C16 acylcarnitine levels are associated with ESRD progression, it remains unclear whether changes in these levels precede eGFR decline, and the potential interference from impaired renal clearance requires further investigation to confirm its utility as a clinical predictor

Am J Physiol Lung Cell Mol Physiol 283:L246L255

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Ce dficit est d'autant plus marqu en prsence de complications microvasculaires