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This reaction is catalyzed by glyceraldehyde-3-phosphate dehydrogenase (GAPDH), yielding the high-energy compound (X~P), 1,3-bisphosphoglycerate (1,3-BPG)

While in healthy young individuals, protein metabolism is regulated by a balance of proteolytic and anabolic processes, there is a lack of an appropriate protein synthesis accompanied by a progressive degradation during sarcopenia, ultimately leading to physical frailty in older people

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doi: 10.1016/0306-3623(94)00203-Y

Toward precision medicine in Alzheimer's disease