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It acts by directly binding to a specific pocket located away from the active site of GK, which enhances its ability to bind with glucose (Chow et al

These include slower dose escalation schedules (microdosing protocols starting at 0.25 mg or lower weekly increments), consistent meal timing, avoiding high-fat foods during dose adjustment periods, and co-prescribing antiemetics temporarily if needed

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Vascular Pharmacology , 113, 6475

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