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1 Introduction Epilepsy is the 4th most common neurological disorder, with a prevalence of over 2.2 million in the United States and 65 million worldwide ( To achieve nutritional ketosis on MAD, restrictive carbohydrate and moderate protein intake coupled with a high fat consumption is necessary ( The majority of carnitine studies have focused on the pediatric population

The most common were gastrointestinal in nature: Nausea Diarrhea Vomiting Constipation Importantly, these events were most prevalent during the initial dose-escalation phases

These mechanisms of DA regulation may have been differently affected in the SNc and VTA by chronic exposure to opioids [60], which could lead to differences in DA release in the dorsal and ventral striatum during NPW

Certainty of evidence was evaluated using the GRADE methodology

Quality control procedures have benefited as a result

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