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While compounded semaglutide may be appropriate in rare, clinically justified situations, FDA-approved medications remain the preferred standard

193 Furthermore, GLP-1R activation suppresses oxidative stress and inflammatory responses in vascular smooth muscle cells (VSMCs), contributing to the stabilization of atherosclerotic plaques

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Dysregulation of this signaling pathway can decrease complex I functioning, resulting in increased production of reactive oxygen species (ROS), mitochondrial malfunction, and eventually dementia (Rai et al., 2019)

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