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Allergic reactions to Abreva are uncommon but serious

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Degradation by the 26S proteasome is coordinated by three different types of ATP-dependent enzymes (E1, E2, and E3) that ubiquitinate the substrate and sensitize it to degradation (Scheffner et al, 1995)

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Color change: Any shift from clear/colorless to yellow, amber, or brown suggests oxidation