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Discuss persistent intense cravings, unexplained weight changes, or symptoms of depression or disordered eating at scheduled follow-up appointments for appropriate evaluation and treatment adjustments

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TGR inhibitors do not react covalently with GSH, selenocysteine, or TGR, and inhibition of TGR is reversible To evaluate stability of the TGR inhibitors in the presence of GSH and selenocysteine, compound 2 and a known covalent inhibitor of TGR, TRi-1 20,45 , were incubated with GSH or the N-Boc protected methyl ester of selenocysteine, and the reaction mixtures were analyzed by LCMS (Supplementary Figs

PLoS One 12 (2), e0171612

10.1016/j.cell.2016.05.041 Cell