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It works directly in the central nervous system by interacting with what is called the melanocortin system , specifically binding to the MC3R and MC4R receptors in the brain

The molecule also helps regulate inflammation by modulating the nuclear factor-kappa B (NF-B) pathway, a key regulator of inflammatory responses

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This occurs by the activation of signal transduction pathways involved in the control of transcription of GCLC and GCLM genes but also there is some evidence of mRNA stabilization by oxidants and electrophiles (Liu et al., 1998)

9 Insulin-like growth factor-binding protein complex acid labile subunit