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In preclinical heart failure models, NNMT enzyme inhibition markedly reduced cardiac 1-MNA (by 77.1%), improved cardiac function, reduced left ventricular hypertrophy and fibrosis, and decreased pro-inflammatory gene expression

2023, Mar, 20;8(1):132 Vargas AJ, Harris CC

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Stable knockdown of HCC cells A lentiviral-mediated approach was used to construct stable NRF2 or TMBIM1 knockdown HCC cell lines

637 Both astrocytic reactivity and astrocytic atrophy with loss of function are observed in affected brain regions in PD