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Modica S, Straub LG, Balaz M, Sun W, Varga L, Stefanicka P, Profant M, Simon E, Neubauer H, Ukropcova B, Ukropec J, Wolfrum C

The cost of GLP-1 medications varies based on insurance coverage and individual plan benefits

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It produces more modest weight loss than GLP-1 agonists (typically 35% body weight)

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Retatrutide's GCGR agonism is the most likely pharmacological explanation - glucagon has documented effects on sensory and autonomic nervous system function - and the dose-dependence (absent at lower doses, material at 9 and 12 mg) supports that hypothesis