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Stress is defined as a biological response to perceived environmental or physiological threats that disrupt the homeostasis of an animal

Aggravated accumulation of S disrupts mitochondrial biogenesis and function by dysregulating the AMPK-CREB-PGC-1 pathway (Shi et al., 2005), which regulates Sirt3 and mitochondrial defence (Park et al., 2020), reported that restoration of Sirt3 expression through the AMPK agonist 5-aminoimidazole-4-carboxamide riboside (AICAR) could recover mitochondrial dynamics and mitophagy

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Berberine activates an enzyme (AMPK) that affects metabolism

Sultana DA, Piroddi R, Galli M, Butterfield F