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Studies show 2-10 fold elevations in mean GH levels that persist throughout the week, while importantly maintaining the natural pulsatile secretion pattern rather than creating unnatural constant elevation
However, it had lower sensitivity compared to CA-125 in ovarian cancer patients
Recently, a hybrid model (cuprizone autoimmune encephalitis or CAE) combining the myelin-toxic effects of cuprizone (Zirngibl et al., 2022) together with an immune stimulation identical to EAE but without extrinsic myelin peptides, provided proof-of-principle for the notion that a primary biochemical dysmyelination can result in a very typical inflammatory demyelinating white matter lesion in an immune-stimulated host (Caprariello et al., 2018)
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10.1016/j.ceb.2010.10.012 Curr Opin Cell Biol
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