Int J Pediatr
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In the intermediate to late stages of AD, most models show that pathogenic events and cognitive impairment emerge rapidly
cAMP activates protein kinase A, resulting in closure of ATP-sensitive potassium channels and depolarization of beta cells, leading to the opening of voltage-gated calcium channels on the cell membrane and exocytosis of insulin-containing granules released from the endoplasmic reticulum due to calcium release [36]
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