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16 However, a separate study didnt find a significant difference in clinical worsening of retinopathy or in need for intervention between GLP-1 RAs and SGLT-2is

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The primary inflammatory mechanisms contributing to the pathogenesis and progression of EDC primarily involve dysregulated tryptophan (Trp) metabolism and dysfunction of classical neurotransmitter systems

Mounjaro's dual GIP/GLP-1 mechanism may confer additional metabolic benefits, though long-term comparative effectiveness studies are ongoing